ED treatment review
Erectile Dysfunction Treatment Review
Overcoming impotence with phosphodiesterase Type 5 inhibitors
The following ED treatments review considers the workings of the 3 most well known ED medications.
These PDE5 (phosphodiesterase type 5) inhibitors are the active ingredients of popular ED tablets branded Cialis, Viagra and Levitra.
Pfizer marketed the first ED tablet branded Viagra. Pfizer is an international pharmaceutical company that also manufactures many other medications worldwide.
Viagra was the initial PDE5 Inhibitor for the treatment of impotence in the late nineties.
Tadalafil is the oral PDE5 inhibitor and basis of the ED drug branded as Cialis®.
Eli Lilly distributes Cialis. Tadalafil is the longest lasting ED pill of the other popular ED medications.
The discomfort concerning the stigma of ED (erectile dysfunction) is decreasing
This ED treatments review acknowledges the social awkwardness surrounding the occurrence of ED (or impotence). The stignma surrounding ED is still present but is decreasing.
This improvement, to some extent, was due to the introduction of Viagra in the late 20th century that improved ED interventions, treatments and cures. From then on, the common understanding of impotence has increased, as has appeals for ED treatments.
Concerning the available ED treatments, PDE5 inhibitors namely Cialis, Viagra and Levitra are the verified method and this ED treatment review examines all 3 impotence treatments available.
As indicated previously, this comparison looks at three effective PDE5 inhibitors such as Sildenafil citrate, Tadalafil and Vardenafil HCl. All these ED treatments produce similar results and have complimentary structural make-ups.
Vardenafil and Sildenafil have similar molecular characteristics. Cialis is structurally different shown in its molecular characteristic which makes this ED pills review a straightforward project.
Erectile dysfunction – the condition and social ramifications
Erectile dysfunction is a failure to experience an erect penis of needed stiffness to engage in sexual penetration. This is a condition usually due to ageing and this condition becomes more noticeable in male subjects over 40.
Previously, experts presumed erectile dysfunction was either a psychosomatic issue or simply a part of getting older. Now experts recognise, erectile dysfunction as chiefly biological – a consequence of somatic neurological complications.
On the other hand, ED may indicate lesser known bodily misalignments. For example, male subjects with vascular problems, like cardiovascular disease and diabetes, have a high incidence of erectile dysfunction.
Erectile dysfunction can frequently show to be a significant indicator for undiagnosed organic disorders. This includes high blood pressure, diabetes, ischaemic heart problems.
ED still remains not sufficiently diagnosed and cured by medical professionals. The social awkwardness about discussing erectile dysfunction is decreasing. But the stigma felt by men continue to block sufficient diagnosis and adequate ED treatment.
The awkwardness around communicating about ED blocks adequate diagnosis and treatments offered.
As a result, many male subjects put up with varying degrees of erectile dysfunction prior to sincerely seeking treatment. In addition, many health boards offer little concern regarding this condition.
Consequently, there is a lack of resources for ED treatments. A lot of men who experience erectile dysfunction fail to receive proper treatment. However, they have much to gain from proper examination and treatment.
A lot of professionals in the medical establishment view this as a lost opportunity. A failure for men in general, not only to prevent or treat erectile dysfunction.
This ED treatment review looks at this imbalance. It helps both those who experience ED as well as professionals gain firmer idea of the ED treatments now available.
The role of PDE5 inhibitor ED tablets
ED tablets enhance the life of erectile dysfunction sufferers. It can also reawaken the sexual capacity of men to a previously enjoyed condition.
There is a leaning towards ED tablets that prolong the time of effectiveness. This facilitates sexual intercourse that is more spontaneous.
As well as using ED tablets, lifestyle changes are beneficial to enhance sexual capacity.
Helpful alternatives to erectile dysfunction medications
A test involving over hundred male subjects found that simply changes in lifestyle lead to in an improvement of sexual function of roughly a quarter of the subjects.
The two most significant factors to decrease the severity of impotence were weight reduction and increased cardioid-vascular activity.
For the majority, the impotence levels did not significantly improve by other changes. This indicates the majority of subjects who have erectile dysfunction still need that ED treatments.
Surgical alternatives to PDE5 Inhibitor drugs
Splints, pumps, injections and surgery are alternative ED treatments.
Clearly the majority of male subjects choose friendlier oral PDE5 inhibitors (ED tablets) and they remain the number one pick.
A reduction in more intrusive cures for impotence due to the use of more economical ED tablets. ED tablets such as generic Cialis and generic Viagra. They cheap to buy from online pharmacies or from a doctor.
Due to this the WHO now stipulates ED tablets, namely Levitra, Viagra and Cialis, as the preferred ED treatment in the first instance. These are the PDE5 blocker ED tablets with the highest track record of success.
As a result both the anticipation of patients and the established positive results of ED tablets have improved dramatically.
Popular PDE5 inhibitors sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra)
The initial PDE5 inhibitor was Sildenafil sold as Viagra® or generic Viagra. People will know sildenafil under various other names such as Kamagra, Vigora, Suhagra, to name a few. They all contain the same PDE5 inhibitor Sildenafil of various strengths from 25mg up to 200mg per tablet.
After Viagra was licensed for wide use a smorgasbord of ED treatments came on the market as effective erectile dysfunction treatments, most well-known ones being Tadalafil (Cialis) and Vardenafil (Levitra).
Cialis (Tadalafil) and Levitra (Vardenafil) both have slightly different properties over the first marketed oral PDE5 inhibitor (Sildenafil).
Millions of men worldwide use PDE5 inhibitors. However, they are not suitable for stroke patients. Also they are not suitable for patients with other health conditions like kidney disease that requires dialysis, cardiac failure, excessive high blood pressure, seriously low blood pressure, or significant damage to the liver.
In these situations doctors should examine the detailed information for every particular ED treatment available to prescribe.
This is because the evidence that each oral PDE5 inhibitor (or ED tablet) contains somewhat different pharmacological effect on the patient apart from the fact that the chemical mechanism of the three PDE5 blockers, Cialis, Viagra and Levitra, are largely identical.
How oral phosphodiesterase type 5 inhibitor impotence drugs work
Here’s the method by which the phosphodiesterase type 5 inhibitors of Cialis, Viagra, Levitra, and other ED medication work:
The male sex organ only becomes enlarged as a result of erotic arousal. Sexual stimulus results in the release of nitric oxide which then results in the expansion of the arteries and veins into the corpus cavernosum, the shaft of the organ, joined with the growing production of cGMP (cyclic guaosine monophosphate).
Unfortunately for a lot of men, particularly as they age, the levels of cGMP necessary to allow a full erection is degraded by the growing levels of PDE5.
Sildenafil, Tadalafil and Vardenafil, active ingredients employed in impotence tablets such as Levitra,Viagra and Cialis, are PDE5 Inhibitors and very effective ED treatments.
By reducing the presence of PDE5 increasingly present in ageing men, these PDE5 blockers permit natural ridged male members to develop.
PDE5 blockers only become activated when cyclic guaosine monophosphate synthesis is also active.
Viagra, Cialis and Levitra require sexual arousal to be effective
Needless to say, ED treatments that use phosphodiesterase Type 5 Inhibitors sexual stimulation to work.
After sexual arousal of the male subject, the nerve endings adjacent to the male organ’s corpus cavernosum releases nitric oxide.
As a result there forms an inflow of cGMP (cyclic guaosine monophosphate) manufactured from GTP that releases the membrane that in turn leads to an erection to the cavity being filled up with fluid.
PDE5 inhibitors block the deterioration of cGMP that then allows penile erections to manifest without difficulty.
Impotence pills that use oral PDE5 inhibitors as the active ingredient are becoming increasing sought after.
These erectile dysfunction drugs utilize chemicals originating from cGMP and with regards to Cialis, Viagra and Levitra their established pharmacokinetic structures are close.
Unlike Vardenafil and Sildenafil, the main PDE5 blockers of well-known erectile dysfunction pills sold as Levitra and Viagra, Tadalafil, the active substance in the much used impotence medication Cialis, has a slightly different chemical property despite including the main characteristics required for the inhibition of PDE5.
The dissimilarities in pharmacokinetic structure could be considered with the chemical structure inherent in the PDE5 inhibitor Tadalafil.
How Tadalafil interacts with various PDE isoenzymes needs to be taken into account in any genuine ED treatment review.
Impotence pills comparison – pharmacokinetic characteristics of PDE5 blockers
PDE enzymes have been identified in eleven distinct instances. They have been listed according to the amino acid structure as well as their response to retardation.
Lab-based studies have shown that the PDE5 inhibitors used in curing erectile dysfunction suppress PDE enzymes in their own ways.
By and large all oral PDE5 inhibitors prescribed effectively suppress PDE5. However, the 3 oral PDE5 inhibitors discussed here, Vardenafil, Sildenafil and Tadalafil, have different characteristics when it comes to blocking other phosphodiesterase enzymes.
Unintended inhibition of phosphodiesterase Type 6 and phosphodiesterase Type 11
Sildenafil and Vardenafil often manifest eyesight abnormality
Out of the three phosphodiesterase Type 5 inhibitors examined, some indicate a propensity to retard the uptake of phosphodiesterase type 6, an enzyme that controls the gathering of light in eyes.
The inhibition of PDE6 affects the experience of the colour spectrum in male subjects. It is reported as a bluish hue to ones vision field.
Reviews in the laboratory show that Viagra and Levitra occasionally results in suppression of PDE6 and as such introduces a slight alteration of light perception.
Cialis does not result in a similar capacity for PDE6 retardation.
Studies have demonstrated that Vardenafil has 3 times the capacity to retard PDE5 than PDE6.
Viagra has 7 times the predilection to inhibit PDE5 over PDE6.
Cialis conversely has 700 times the propensity to suppress PDE5 than PDE6.
Tadalafil has a greater propensity to suppress PDE11 than Vardenafil and Sildenafil. The function of PDE11 remains mysterious however.
How quickly are ED treatments sildenafil, vardenafil and tadalafil absorbed quickly into the blood stream after ingestion?
Sildenafil and vardenafil oral PDE5 inhibitors reach peak accumulation in a shorter timespan than Tadalafil PDE5 inhibitor.
After swallowing, Viagra PDE5 blocker gets to a top concentration somewhat less than 60 minutes.
Vardenafil achieves its greatest accumulation in close to 60 minutes.
Tadalafil requires approximately 120 minutes to achieve its peak accumulation.
ED treatment review – The effects of alcohol and various food on PDE5 blockers.
Fatty-based foods in the subject’s ingestion tract prior to swallowing has shown to partly block the absorption of sildenafil and vardenafil but shows little if any effect on the uptake of tadalafil.
Potency of Viagra and Levitra lessened by food with high fat content.
If one consumes fatty food content before taking Viagra PDE5 inhibitor (Sildenafil), the absorption slows down by up to 60 minutes.
Similar to Viagra, fatty food content also retards the uptake of Levitra for up to 60 minutes.
Likewise, the top concentration is lowered around 20%.
What this means is that if you are combining Viagra or Levitra with fat-based foods you may have to increase the dosage to feel the same effects.
Cialis not degraded by food with high fat content consumption
The presence of food with high fat content does not decrease the effect of Cialis, unlike Levitra and Viagra.
Alcohol consumption does not affect all three PDE5 inhibitors. However, excessive consumption of alcohol does seem is a factor in causing ED.